fentanyl transdermal and diazepam each increase sedation. Keep away from or Use Alternate Drug. Restrict use to people for whom alternate cure solutions are insufficient
crofelemer raises amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Crofelemer has the opportunity to inhibit CYP3A4 at concentrations anticipated in the intestine; not likely to inhibit systemically because minimally absorbed.
Valium is contraindicated in individuals that has a acknowledged hypersensitivity to diazepam and, as a result of deficiency of enough scientific encounter, in pediatric sufferers underneath six months of age. Valium is also contraindicated in clients with myasthenia gravis, severe respiratory insufficiency, critical hepatic insufficiency, and slumber apnea syndrome.
Stay away from or substitute An additional drug for these medications when possible. Examine for lack of therapeutic impact if medication need to be coadministered. Change dose As outlined by prescribing information and facts if needed.
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If this is not possible, give drug into tubing of a flowing IV Alternative as near as feasible to vein insertion
It's also advisable to keep away from ingesting Liquor and making use of leisure medicines when taking diazepam, since it can make you more sensitive to the consequences of those substances.
iloperidone raises amounts of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Iloperidone is often a time-dependent CYP3A inhibitor and will bring on increased plasma levels of medications predominantly eradicated by CYP3A4.
diazepam will enhance the amount or result of tinidazole by impacting hepatic/intestinal enzyme CYP3A4 website metabolism. Use Caution/Keep an eye on.
primidone will reduce the level or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
With newborn infants it have to be remembered that the enzyme system involved in the breakdown in the drug is not really nonetheless fully designed (especially in untimely infants) fifteen.
Right before use, instruct unique administering diazepam intranasal on how to determine seizure clusters and the way to appropriately administer the products
fentanyl transmucosal and diazepam both equally enhance sedation. Stay away from or Use Alternate Drug. Limit use to patients for whom choice therapy solutions are insufficient
mitotane decreases levels of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Mitotane is a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for possible dosage adjustments.